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Combination of cyclophosphamide and estrogen therapy in dmba‐induced rat mammary cancer
Author(s) -
Kiang David T.,
Kennedy B. J.
Publication year - 1971
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(1971)28:5<1202::aid-cncr2820280518>3.0.co;2-d
Subject(s) - cyclophosphamide , medicine , estrogen , dmba , breast cancer , estrogen therapy , mammary tumor , cancer , endocrinology , combination therapy , chemotherapy , oncology , cancer research , carcinogenesis
The effect of estrogen plus cyclophosphamide combination therapy was evaluated in DMBA‐induced mammary tumors in rats. These tumors were stimulated by estrogen therapy, especially when low doses were used. Well‐differentiated tumors were more vulnerable to this stimulation. A tumor, once stimulated by low‐ dose estrogen therapy, could progress or regress under the continuation of therapy and this outcome seemed to be related to its original growth pattern. Cyclophosphamide significantly inhibited the initial stimulatory effect induced by estrogen therapy. However, it also reduced the regression rate induced by high doses of estrogen. A corollary to human breast cancer may exist.