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Primary squamous cell carcinoma and adenoacanthoma of the colon
Author(s) -
Comer Thomas P.,
Beahrs Oliver H.,
Dockerty Malcolm B.
Publication year - 1971
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(1971)28:5<1111::aid-cncr2820280504>3.0.co;2-v
Subject(s) - anaplasia , adenocarcinoma , medicine , epithelioma , epidermoid carcinoma , rectum , basal cell epithelioma , carcinoma , pathology , basal cell , cancer , surgery
Squamous cell carcinoma and adenoacanthoma rarely occur in the colon or upper rectum and are seen 0.05% as frequently as adenocarcinoma. At the Mavo Clinic, 20 patients with these lesions were seen during a 60‐year period. The most plausible explanation for the occurrence of these lesions is that glandular epithelioma is destroyed by deleterious influences and replaced by proliferation of basal cells which, with repeated destruction, undergo anaplasia and loss of ability to redifferentiate normally. The surgical treatment of these tumors is the same as that for adenocarcinoma. The 5‐year survival rate for patients with adenoacanthoma and squamous cell epithelioma is 30%, compared to 50% for patients with glandular cancers.