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Ultrastructure of congenital fibrosarcoma
Author(s) -
GonzalezCrussi Frank
Publication year - 1970
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197012)26:6<1289::aid-cncr2820260616>3.0.co;2-r
Subject(s) - ultrastructure , pathology , fibrosarcoma , mesenchymal stem cell , medicine , embryonic stem cell , anatomy , biology , genetics , gene
A malignant mesenchymal tumor having its inception during intrauterine life is described. Clinical and histopathologic features conformed to established criteria for congenital fibrosarcoma. Ultrastructurally, the predominant cells were interpreted as embryonic fibroblasts. A second cell type, possibly related to the predominating cells, was characterized by greater structural complexity. Abundant deposits of electron‐dense material were a salient feature of the neoplasm, but their significance was not defined. Despite the prominence of intercellular substance production, there was little evidence of collagenization. It is speculated that ultrastructural evidence of enhanced synthetic activity, rapid maturation, and meager cell‐to‐cell cohesion are features of importance in correlation with the known local aggressiveness of these tumors. The ultrastructural appearance described is at variance with published observations of purportedly related lesions that show close similarities when studied by conventional histologic techniques.