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Acquired coagulation factor deficiencies in leukemia
Author(s) -
Gralnick Harvey R.,
Henderson Edward
Publication year - 1970
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197011)26:5<1097::aid-cncr2820260518>3.0.co;2-2
Subject(s) - medicine , hemorrhagic diathesis , leukemia , coagulation , mechanism (biology) , acute leukemia , factor v , factor ix , gastroenterology , immunology , thrombosis , epistemology , philosophy
Isolated Factor V and X deficiencies were associated with acute leukemia in 2 patients. Both patients manifested a hemorrhagic diathesis. in the patient with Factor V deficiency, the level of Factor V was related to the activity of his leukemia. the mechanism of these deficiencies is unclear, but therapy should be directed to correcting the hemostatic mechanism until a hematologic remission can be attained.