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Pleural mesothelioma associated with massive hepatic calcification and unusual metastases
Author(s) -
Persaud Vasil,
Bateson Eric M.,
Bankay Clarence D.
Publication year - 1970
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197010)26:4<920::aid-cncr2820260428>3.0.co;2-p
Subject(s) - medicine , calcification , mesothelioma , radiography , radiology , pathology
A case of diffuse, malignant, pleural mesothelioma is reported in a 60‐year‐old Negro man the clinical picture was most unusual; when the patient presented initially with chest pain, the radiographic appearances in the chest were normal, but extensive liver calcification was demonstrated the latter was subsequently shown to be caused by metastases from the mesothelioma which took 2 more years to produce clinical and radiographic changes in the chest. There was microscopic evidence that the extensive liver calcification was dystrophic in nature and had resulted from marked degenerative changes and necrosis in the metastatic tumor. No references to massive hepatic calcification caused by metastatic malignant pleural mesothelioma could be found in the literature. Radiographs of the skeleton revealed focal, translucent lesions with sclerotic margins in the right seventh rib and the right iliac bone. Similar changes were shown on postmortem roentgenograms of the skull. Microscopic examination showed these bony lesions to be metastases. No previous report of secondary deposits in bone producing such radiographic appearances could be found in the literature.