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The hemoglobin profile and erythroleukemia
Author(s) -
Horton Bennett F.,
Chernoff Amoz I.,
Meadows Robert W.
Publication year - 1970
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197010)26:4<904::aid-cncr2820260425>3.0.co;2-o
Subject(s) - fetus , hemoglobin , fetal hemoglobin , medicine , leukemia , hexokinase , stem cell , dehydrogenase , malignant cells , hemoglobin f , pathology , physiology , biology , biochemistry , enzyme , pregnancy , cancer , microbiology and biotechnology , metabolism , genetics , glycolysis
The red blood cells of a 7‐year‐old girl with erythroleukemia contained about 60% fetal type hemoglobin, reduced quantities of both Hb A 2 and acetyl‐cholinesterase, elevatd activities of glucose‐6‐phosphate dehydrogenase, and a hexokinase pattern similar to that of a neonate. She experienced thrombocytopenia with bleeding, a poor response to therapy, and a short survival. Her course, and that of several other published cases, may support the theory of Lucarelli et al., which postulates the existence of distinct fetal and adult hematologic stem cells. Presence of fetal characteristics in red cells of patients with leukemia suggests that malignant cells may be of fetal origin in contrast, other types of leukemia are associated with red cells having adult characteristics which, presumably, originated from adult hematologic stem cells.