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Ultrastructure of mycosis fungoides
Author(s) -
Brownlee Thomas R.,
Murad Tariq M.
Publication year - 1970
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197009)26:3<686::aid-cncr2820260330>3.0.co;2-x
Subject(s) - mycosis fungoides , pathology , endoplasmic reticulum , cytoplasm , ultrastructure , golgi apparatus , organelle , cell , chemotherapy , medicine , necrosis , lymphoma , biology , microbiology and biotechnology , biochemistry
Six biopsies from 5 cases of treated and untreated mycosis fungoides were studied with the light and electron microscope. The study revealed the presence of a characteristic cell type in the skin lesions. The characteristic cells had large infolded nuclei, scant cytoplasm, and few organelles. Mitochondria were clustered in one region of the cytoplasm in which the Golgi apparatus was found. Treatment with systemic corticosteroids and electron beam therapy caused no significant change in the mycosis fungoides cells. Treatment with chemotherapy appeared to damage the malignant cells to a lesser extent than the surrounding cells. The combination of chemotherapy and x‐irradiation caused smoothening of the nuclear envelope, vesiculation of the endoplasmic reticulum, mitochondrial swelling, and the appearance of membrane‐bound lysosome‐like bodies. These changes were seen in both the mycosis fungoides cells and in other cell types present in the cutaneous lesions. No method of treatment produced necrosis in the mycosis fungoides cells.