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A study of environmental influence upon salivary gland neoplasia in rats
Author(s) -
Rowe Nathaniel H.,
Grammer Frank C.,
Watson Francis R.,
Nickerson Norton H.
Publication year - 1970
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197008)26:2<436::aid-cncr2820260227>3.0.co;2-v
Subject(s) - weanling , medicine , physiology , vitamin , salivary gland , endocrine system , endocrinology , carcinogen , cancer , hormone , biology , biochemistry
An animal model system was used in an attempt to explore suspect relationships between 3 groups of possible carcinogenic co‐factors (nutritional, endocrine, and thermal) and the seemingly high salivary gland cancer experience of Arcticdwelling Eskimos. Two hundred and thirty weanling Sprague‐Dawley rats were randomized into 7 groups to study effects of vitamin A deficiency, hypercortisonism, hyperthyroidism, hypercortisonism plus hyperthyroidism combined, and a windy, cold, humid environment upon submaxillary salivary glands challenged with implanted 20 percent 7,12‐dimethylbenzanthracene pellets. Animals were sacrificed at 14 weeks. Of the 7 regimens, only vitamin A deficiency increased malignant epithelial neoplasm yield. Increased yield in vitamin A deficient group (I) compared to the sum of nutritionally adequate control groups (II and III) was significant at the 0.001 level, and with all groups II‐VII individually (p = 0.0001) or combined (p = 0.00004). No significant yield difference was found among the other 6 groups (II‐VII).