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“Seminoma with trophocarcinoma”. A clinical variant of seminoma
Author(s) -
Friedman Milton,
Pearlman Alexander W.
Publication year - 1970
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197007)26:1<46::aid-cncr2820260106>3.0.co;2-h
Subject(s) - seminoma , medicine , dysgerminoma , radiation therapy , pathology , choriocarcinoma , chemotherapy , ovary
Seminoma occasionally contains foci of trophocarcinoma (embryonal carcinoma), or else has histologic features of aggressive growth. The resultant variants are classified into: anaplastic seminoma, borderline seminoma, and seminoma with trophocarcinoma. The latter variant is characterized by specific histologic features and, compared with pure seminoma, by more aggressive clinical behavior, larger required tumor lethal radiation dose, and lower survival rate. The intimate association of primordial trophoblastic structures with seminoma is of histogenetic interest.