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Relation of gravidity and age to prognosis and clinical stage in uterine cervix cancer
Author(s) -
Kurohara Samuel S.,
Selim Mostafa A.,
Graham John B.
Publication year - 1970
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197007)26:1<39::aid-cncr2820260105>3.0.co;2-c
Subject(s) - medicine , cervix , stage (stratigraphy) , uterine cervix , obstetrics , cancer , gynecology , cervical cancer , disease , pregnancy , carcinoma , paleontology , genetics , biology
The relation of gravidity and age to prognosis and clinical stage was evaluated in 4,546 primary cases of uterine cervix cancer seen during 1920 through 1953. Maximal survival rates associated with relatively early cancers were observed in patients who had moderate numbers (1, 2, or 3) of pregnancies prior to diagnosis. Lower rates associated with more advanced disease were observed in those with none or many previous pregnancies. These relationships were not observable i n patients in whom cancer was diagnosed after the fifth decade of age. There is a possibility that these clinical alterations may be explained by certain pathophysiologic changes occurring in the cervix with successive pregnancies and age.