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Immunologic status of host and response of a methylcholanthrene‐induced sarcoma to local x‐irradiation
Author(s) -
Suit Herman D.,
Kastelan Andrija
Publication year - 1970
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197007)26:1<232::aid-cncr2820260129>3.0.co;2-d
Subject(s) - methylcholanthrene , fibrosarcoma , medicine , transplantation , neoplasm , immune system , irradiation , sarcoma , immunology , cancer research , pathology , carcinogen , biology , genetics , physics , nuclear physics
A methylcholanthrene‐induced fibrosarcoma of C 3 H/He mice has been submitted to a series of TD 50 and TCD 50 assays. TD 50 is number of cells to transplant tumor into half of the recipients; TCD 50 is radiation dose which yields control of half of the irradiated tumors. The TD 50 was greater by a factor of 100 for transplantation into actively immunized mice instead of 400 rads whole body irradiated animals (24 hours earlier). The TCD 50 values were 4,300 rads, 3,500 rads, and 2,700 rads for tumors transplanted into immunologically depressed mice, normal mice, and actively immunized mice, respectively. This difference in TCD 50 would correspond to a killing by radiation dose of 100 times fewer cells in the actively immunized mice than in 400 rads' irradiated mice. There was no effect of the radiation‐induced changes in normal tissue to block the efficacy of the immune rejection response to increase TD 50 . Finally, attempts to enhance the immunologic rejection response being mounted by a normal mouse against an established tumor were not successful.