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Erythropoietin levels in patients with renal tumors or cysts
Author(s) -
Murphy Gerald P.,
Kenny Gerald M.,
Mirand Edwin A.
Publication year - 1970
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197007)26:1<191::aid-cncr2820260124>3.0.co;2-s
Subject(s) - medicine , erythropoietin , renal cell carcinoma , cyst , kidney , metastasis , urology , endocrinology , pathology , cancer
Increased erythropoietin (ESF) values have been observed in 49 plasma samples and in 14 cyst fluids of 92 patients with renal cell carcinomas or renal cyst. High levels of ESF and, sometimes, erythrocytosis were observed in patients with renal carcinoma. Patients with renal cysts frequently had highly elevated ESF levels but not erythrocytosis. The elevated levels of ESF and erythrocytosis subsided upon the removal of the renal carcinomas. Elevated ESF levels fell following cyst excision. The highest levels of ESF were observed in patients developing metastasis after the removal of renal carcinoma. Moreover, androgen therapy in these patients with metastasis produced further substantial elevations of ESF levels. These studies provide evidence that renal neoplasms and renal cysts serve as aberrant sites of ESF production and/or storage of ESF. Also, the erythrocytosis seen in some of these patients with renal disorders is ESF‐dependent. This is unlike the erythrocytosis of polycythemia vera, which is not ESF‐dependent.