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Observation of cells resembling sternberg‐reed cells in conditions other than Hodgkin's disease
Author(s) -
Strum Stephen B.,
Park Jung K.,
Rappaport Henry
Publication year - 1970
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197007)26:1<176::aid-cncr2820260123>3.0.co;2-i
Subject(s) - reed–sternberg cell , pathognomonic , pathology , cytoplasm , disease , medicine , biopsy , malignant cells , lymphoma , biology , cancer , microbiology and biotechnology , hodgkin lymphoma
The diagnosis of Hodgkin's disease is based upon the finding of characteristic Sternberg‐Reed cells in appropriate cellular and architectural environments. The demonstration of cells with the nuclear and cytoplasmic features of Sternberg‐Reed cells is necessary, but not sufficient for the diagnosis of this disease. Many investigators, however, have erroneously regarded these cells as pathognomonic. This report emphasizes that cells indistinguishable from, or closely resembling, Sternberg‐Reed cells may be found in conditions other than Hodgkin's disease. Their presence, therefore, should not be considered a diagnostic mandate. Thirteen cases are presented in which biopsy sections of both benign and malignant lesions revealed cells closely resembling or indistinguishable from Sternberg‐Reed cells.