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Alkaline phosphatase in meningiomas
Author(s) -
Timperley W. R.,
Warnes T. W.
Publication year - 1970
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197007)26:1<100::aid-cncr2820260112>3.0.co;2-a
Subject(s) - alkaline phosphatase , meningioma , phosphatase , homogeneous , biochemistry , enzyme , urea , chemistry , medicine , microbiology and biotechnology , biology , pathology , physics , thermodynamics
Alkaline phosphatase was extracted from 5 meningiomas, and several of its biochemical properties were compared with alkaline phosphatase from normal serum and extracts of small intestine. The meningioma phosphatases behaved in a reasonably homogeneous manner. They were virtually uninhibited by 0.05 M L‐phenylalanine and were remarkably heat sensitive. One molar urea produced a similar degree of inactivation to that obtained with alkaline phosphatase of normal serum. Electrophoretically the alkaline phosphatase of all meningiomas produced a single band moving at the same rate as the main band seen in normal serum.