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A missing group C chromosome in the bone marrow cells of three children with myeloproliferative disease
Author(s) -
Teasdale J. M.,
Worth A. J.,
Corey M. J.
Publication year - 1970
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197006)25:6<1468::aid-cncr2820250627>3.0.co;2-f
Subject(s) - bone marrow , medicine , haematopoiesis , pathology , acute myeloblastic leukemia , bone marrow examination , chromosome , myeloid , leukemia , anemia , immunology , biology , genetics , stem cell , gene
Three children, aged 7 months, 1 year, and 13 years, were found to have anemia and thrombocytopenia. Bone marrow examination showed an increase in myeloid elements in all 3 and a slight increase in blast cells (14%) in the second child. Examination of the bone marrow chromosomes showed a missing group C chromosome in all 3 while peripheral lymphocytes stimulated with phytohemagglutinin gave a predominantly normal 46 chromosome pattern. Serial hematologic and chromosomal analyses of blood and bone marrow were obtained throughout the course of the disease process. All 3 children eventually died from acute myeloblastic leukemia. These cases provide additional evidence in favor of the association between aneuploidy of group C chromosomes and disturbances of hematopoiesis—particularly the myeloproliferative disorders.