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Immunofluorescence of epithelial skin tumors. I. Patterns of intercellular substance
Author(s) -
de Moragas Jose M.,
Winkelmann R. K.,
Jordon Robert E.
Publication year - 1970
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197006)25:6<1399::aid-cncr2820250620>3.0.co;2-x
Subject(s) - epidermis (zoology) , seborrheic keratosis , keratoacanthoma , pathology , keratin , immunofluorescence , medicine , intracellular , basal cell , sweat gland , antibody , carcinoma , biology , sweat , anatomy , immunology , microbiology and biotechnology
Epidermal tumors were studied for production of intercellular substance (ICS) present in normal epidermis. Antibody to ICS found in pemphigus serum was used and detected by immunofluorescent technique. ICS was absent in squamous cell carcinoma, and its absence was related to degree of neoplasia. Individual cell keratinization was related to ICS. Basal cell carcinomas had no ICS, similar to sweat gland tumors. Seborrheic keratosis and keratoacanthoma produced normal amounts of ICS. It appears possible to classify tumors by this technique and probably relate intercellular substance to tumor behavior.