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Changes in mitochondrial ultrastructure in nickel sulfide‐induced rhabdomyosarcoma
Author(s) -
Basrur Parvathi K.,
Sykes Anthony K.,
Gilman J. P. W.
Publication year - 1970
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197005)25:5<1142::aid-cncr2820250519>3.0.co;2-9
Subject(s) - nickel sulfide , mitochondrion , ultrastructure , sulfide , nickel , electron microscope , cell , rhabdomyosarcoma , biophysics , microbiology and biotechnology , pathology , chemistry , biochemistry , biology , medicine , sarcoma , physics , organic chemistry , optics
Ultrastructural features of mitochondria in nickel sulfide‐induced primary rat rhabdomyosarcomas were compared with those of muscle tissues exposed to nickel sulfide in amounts suboptimal for inducing tumors. Tumor cell mitochondria exhibited conformational changes, accumulation of electron dense granules, and elaboration of cristae which appeared to coalesce and form wavy or parallel stacks. Some of these mitochondria were extremely enlarged and appeared to show degenerative changes including disruption of the outer and inner membranes and/or complete replacement of the cristae with 50 to 60 Å thick filaments. Some of these changes were also noted in rat muscle tissues exposed to nickel sulfide for short duration, suggesting that mitochondria altered in response to nickel sulfide are capable of prolonged survival. It would appear that some of the mitochondrial changes induced by nickel sulfide in adult skeletal muscle are adaptive modifications maintained in tumor cells which result from repeated divisions of dedifferentiated muscle cell derivatives.