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A study of free radicals occurring in tumorous female breast tissue and their implication to detection
Author(s) -
Wallace J. D.,
Driscoll D. H.,
Kalomiris C. G.,
Neaves A.
Publication year - 1970
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197005)25:5<1087::aid-cncr2820250513>3.0.co;2-b
Subject(s) - radical , medicine , biopsy , human breast , breast tissue , modified radical mastectomy , radical mastectomy , mastectomy , pathology , breast cancer , cancer , biology , biochemistry
Tissue from 152 human breast lesions was taken at biopsy or mastectomy, and the free radicals were studied. The experience indicated that the smaller cancers had higher free radical concentrations. Based upon this finding and the animal tumor findings of Saprin et al. and Driscoll et al., a mainly theoretical curve has been constructed of the dynamic variation in free radical concentration as a function of tumor doublings. The curve indicates that the peak of activity probably occurs at 20 doublings which is well before usual clinical detection. Thermography has been found to give positive indications when viewed retrospectively.