Premium
Correlation between clinicohistologic staging and extranodal relapse in Hodgkin's disease
Author(s) -
Johnson Ralph E.,
Thomas Louis B.,
Chretien Paul
Publication year - 1970
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197005)25:5<1071::aid-cncr2820250510>3.0.co;2-2
Subject(s) - medicine , radiation therapy , occult , disease , stage (stratigraphy) , histopathology , chemotherapy , lymphoma , histology , b symptoms , oncology , pathology , radiology , paleontology , alternative medicine , biology
The sites of relapse following primary treatment with irradiation have been evaluated in a series of patients with previously untreated Hodgkin's disease. Distinction has been made between relapse of disease in extranodal sites and relapse in lymph nodes. The extranodal relapse rate correlates with both the clinical stage of disease prior to treatment and with histopathology. The highest incidence of extranodal relapse is in patients who initially present with both constitutional symptoms and a tumor histology of mixed cellularity or lymphocyte depletion. Segregation of patients into categories of low and high risk of extranodal relapse defines selected patients who have a significant likelihood of failing to be cured with radiotherapy alone. This provides a rationale for investigating intensive chemotherapy as an adjuvant to radiotherapy in these patients. Chemotherapy would be employed as an integral part of primary treatment with the aim of eradicating small microscopic foci of clinically occult Hodgkin's disease in extranodal sites.