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Effect of duration of breathing 95% oxygen plus 5% carbon dioxide before X‐irradiation on cure of C3H mammary tumor
Author(s) -
Inch W. Rodger,
McCredie John A.,
Sutherland Robert M.
Publication year - 1970
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197004)25:4<926::aid-cncr2820250428>3.0.co;2-c
Subject(s) - carbon dioxide , oxygen , medicine , inhalation , hyperbaric oxygen , breathing gas , anesthesia , breathing , irradiation , room air distribution , surgery , chemistry , physics , organic chemistry , nuclear physics , thermodynamics
Inhalation of 95% oxygen plus 5% carbon dioxide at atmospheric pressure one‐half minute before and during x‐ray therapy increased the rate of cure of the syngeneic mammary tumor in C3H mice. The effect was less when the mice were allowed to breathe the gas for 12 minutes before treatment. When 100% oxygen, at one atmosphere, was breathed before irradiation for one‐half minute or 12 minutes, or at 4 atmospheres for 5 minutes, the rate of tumor cure was increased compared with breathing air at atmospheric pressure. There was no difference between inhaling normobaric 100% oxygen for one‐half minute or 12 minutes, 95% oxygen plus 5% carbon dioxide for 12 minutes, or hyperbaric oxygen. Loss of weight and mortality were greater in mice which inhaled hyperbaric oxygen.