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Lymphocyte transformation changes during the clinical course of Hodgkin's disease
Author(s) -
Jackson S. M.,
Garrett J. V.,
Craig A. W.
Publication year - 1970
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197004)25:4<843::aid-cncr2820250413>3.0.co;2-1
Subject(s) - medicine , disease , lymphocyte , clinical disease , presentation (obstetrics) , immunology , surgery
Forty‐one patients with Hodgkin's disease have been investigated, mostly at their clinical presentation and, on frequent occasions, throughout the clinical course of their disease. A quantitative radioisotopic investigation has been made of the response of the patients' peripheral blood lymphocytes to PHA stimulation. It has been shown that lymphocyte response (lymphocyte transformation) is related to the severity of the disease; at presentation, the majority of patients with early Hodgkin's disease have a normal response and those with systemic symptoms a significantly reduced response. Throughout the course of the disease, the lymphocyte response is associated with the severity of the disease and may show improvement in periods of clinical remission arising from treatment.