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Some characteristics of human cancer tissues in vitro
Author(s) -
Israeli Ella,
Barzilal David
Publication year - 1970
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197004)25:4<824::aid-cncr2820250411>3.0.co;2-6
Subject(s) - histology , medicine , in vitro , pathology , human breast , cancer , tissue culture , carcinoma , cancer cell , biology , genetics
Eighty‐six tumor tissues of diverse histology and origin were cultured in vitro. Some growth characteristics were studied with the aim of establishing criteria which might help in prognosis. It was found that tumors of identical origin and classification differed in their ability to grow in either cell or tissue cultures and, in the effect of cancer ascitic fluid on their growth and in morphology of the developing cultures. The main group of tumors tested was the invasive duct carcinoma of the breast, in which we found a wide spectrum of morphological variations which ranged from well‐organized homogenous cell layers to small colonies of round aggregating cells which detached quickly. These differences will be correlated with the results of the clinical follow‐up being done on the respective patients.