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Clear‐cell carcinoma of the ovary. A clinicopathologic analysis of pure and mixed forms and comparison with endometrioid carcinoma
Author(s) -
Czernobilsky Bernard,
Silverman Barney B.,
Enterline H. T.
Publication year - 1970
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197004)25:4<762::aid-cncr2820250404>3.0.co;2-3
Subject(s) - clear cell carcinoma , clear cell , carcinoma , ovary , medicine , pathology , cell , neoplasm , mesonephric duct , biology , kidney , genetics
A clinicopathologic analysis of 39 primary ovarian carcinomas wholly or partially composed of clear cells was carried out. The histologic concept of “clear cell” was redefined and the ratio of clear to nonclear cell components was evaluated in each case. The tumors were accordingly subdivided into “pure” (12 cases), “predominantly” (7 cases), and “focal” (20 cases) clear‐cell groups. The pathologic and clinical features of each group were then compared to each other. Follow‐up data were also compared with 45 patients with ovarian endometrioid carcinoma. Because of the frequent admixture and transitions of clear‐cell tumors with nonclear‐cell neoplasms of müllerian derivation, it was concluded that the clear‐cell tumors of the ovaries are most likely of müllerian rather than mesonephric origin. Cumulative survival figures in the various groups of clear‐cell carcinoma and in patients with endometrioid carcinoma were similar with a mean 5‐year survival of about 38%. The single most significant feature determining survival in all these patients was the extent of the neoplasm at time of surgery.