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Cyclophosphamide‐induced changes in circulating lymphocyte kinetics in chronic lymphocytic leukemia
Author(s) -
Coco Frank,
Merritt John A.
Publication year - 1970
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197003)25:3<721::aid-cncr2820250333>3.0.co;2-h
Subject(s) - cyclophosphamide , medicine , chronic lymphocytic leukemia , lymphocyte , leukemia , immunology , chemotherapy , gastroenterology , endocrinology
The effects of cyclophosphamide upon circulating lymphocytes were studied in 3 patients with chronic lymphocytic leukemia using autologous lymphocytes labelled with Na 2 51 CrO 4 . Blood and organ radioactivity were studied before therapy, and the results compared with those obtained while each patient was receiving weekly intravenous infusions of cyclophosphamide. Two patients manifested clinical and laboratory evidence of response to the drug. In one of these patients, there was a comparatively greater loss of circulating radioactivity within a few days after the first dose. In the other, the initial curve appeared unchanged while there was increased loss of circulating activity after the first week. There was a relative increase in hepatic radioactivity during therapy in both patients. The third patient did not appear to respond to cyclophosphamide, and only a minimal difference in his lymphocyte kinetics was found during therapy. These observations indicate that the response of circulating lymphocytes to cyclophosphamide may vary in different patients with chronic lymphocytic leukemia, and that the loss of circulating radioactivity is associated with increased hepatic uptake of label.