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Metastatic carcinoma of the male breast treated with bilateral adrenalectomy and chemotherapy
Author(s) -
Li Min C.,
Janelli Donald E.,
Kelly Edward J.,
Kashiwabara Himeko,
Kim Re Hwe
Publication year - 1970
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197003)25:3<678::aid-cncr2820250326>3.0.co;2-n
Subject(s) - medicine , orchiectomy , adrenalectomy , bilateral adrenalectomy , surgery , thiotepa , chemotherapy , gynecomastia , methotrexate , carcinoma , urology , cyclophosphamide
The literature concerning bilateral adrenalectomy as a palliative modality for metastatic male breast carcinoma following orchiectomy is reviewed. Including the present 2 subjects, a total of 17 patients have been reported. Of these 2, one failed to respond to bilateral orchiectomy but responded to bilateral adrenalectomy for 6 months and, when the disease was in relapse, he further responded to chemotherapy using fluorouracil and methotrexate combined with ThioTEPA, respectively. The other patient who failed with orchiectomy showed only symptomatic improvement for a short period following adrenalectomy. The literature indicates bilateral adrenalectomy is a worthwhile procedure even if prior orchiectomy has failed to render remission of the disease.