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Morphology of Burkitt's lymphoma during regression induced by cyclophosphamide
Author(s) -
Osunkoya B. O.,
Ngu V. A.,
Mottram Frances C.
Publication year - 1970
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197003)25:3<505::aid-cncr2820250303>3.0.co;2-g
Subject(s) - cyclophosphamide , medicine , lymphoma , lymphocytic infiltration , infiltration (hvac) , pathology , histiocyte , tumor cells , giant cell , cytology , chemotherapy , cancer research , physics , thermodynamics
The histologic and cytologic features of Burkitt's lymphoma during the first few days following the administration of intravenous cyclophosphamide are described. The 3 cases studied showed almost complete disappearance of tumor cells within 72 hours. Surviving tumor cells were enlarged, and some attained a giant size (“gigantoblasts”). There were differences in the ultimate response of the 3 cases to treatment. One case showed complete regression and total disappearance of tumor cells while in another case, after an initial good response accompanied by massive lymphocytic infiltration at the tumor site, numerous tumor cells reappeared. All cases showed marked histiocytic proliferation and karyophagocytosis. It is considered that the presence of “gigantoblasts” may lead to difficulty in histologic diagnosis of biopsies taken from patients who have been receiving cyclophosphamide.