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Cryosurgery of primate pancreas
Author(s) -
Myers Richard S.,
Hammond William G.,
Ketcham Alfred S.
Publication year - 1970
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197002)25:2<411::aid-cncr2820250220>3.0.co;2-7
Subject(s) - pancreas , medicine , primate , pancreatitis , amylase , lesion , pathophysiology , lipase , cryosurgery , pathology , nonhuman primate , physiology , enzyme , surgery , biology , neuroscience , biochemistry , evolutionary biology
The existing inadequacy in treatment of pancreatic neoplasia prompted this investigation into the pathophysiologic consequences of freezing primate pancreas. Using a liquid nitrogen cryosurgical probe (—150 C), a 3 × 3 cm lesion was made in the distal pancreas of 15 rhesus monkeys. Frequent serial determinations of Hct, WBC, serum amylase, and serum lipase were made. At 6 hours, and 1, 4, 7, 14, 28, and 42 days post‐freeze, 2 animals were sacrificed to obtain histologic specimens. All animals survived without incident and appeared clinically normal until time of sacrifice. There was a marked initial elevation of amylase (average 2400 Somogyi units) and lipase (average 1.5 Teitz units), but these returned to normal within one week. Histologically, typical cryonecrosis occurred in the treated area, while untreated pancreas and surrounding tissue remained normal. This study demonstrates that cryonecrosis of a significant portion of pancreatic tissue can be produced in a primate without the development of diffuse pancreatitis or other ill effects.