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Mithramycin treatment of hypercalcemia
Author(s) -
Perlia Charles P.,
Gubisch Nancy J.,
Wolter Janet,
Edelberg David,
Dederick Margarida M.,
Taylor Samuel G.
Publication year - 1970
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197002)25:2<389::aid-cncr2820250217>3.0.co;2-x
Subject(s) - medicine , malignancy
An experience with Mithramycin in the treatment of hypercalcemia of malignancy is reported. Mithramycin given by direct, single, intravenous injection of 25 μg/kg was effective in lowering serum calciums within 24 to 48 hours in the majority of patients studied. The duration of this effect has been quite variable, but repeated doses of single injections have proven to be successful in most cases treated. The potential clinical usefulness of this agent in the treatment of hypercalcemia is apparent. It is reasonable to continue such studies on a long‐term basis. Such studies are currently in progress.