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Retained regional lymph nodes: Effect on metastases and recurrence after tumor removal
Author(s) -
Hammond William G.,
Rolley Ronald T.
Publication year - 1970
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197002)25:2<368::aid-cncr2820250214>3.0.co;2-a
Subject(s) - medicine , lymph , immunogenicity , surgery , seeding , metastasis , tumor cells , incidence (geometry) , distant metastasis , cancer , pathology , cancer research , immune system , immunology , physics , optics , engineering , aerospace engineering
Using a syngeneic mouse sarcoma of recent origin and demonstrable immunogenicity, the effects of removal or retention of regional lymph nodes upon development of local recurrences and distant metastases were studied. Irrespective of extent of operation, early tumor removal prevented development of distant metastases while delayed tumor excision was followed by distant metastases in about half the animals so treated. Significant and comparable incidences of local recurrence were noted after early operations with deliberate postoperative wound seeding with tumor and after late operations without wound seeding, whereas early operation without wound seeding resulted in a negligible incidence of local recurrence.