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Toxicity of E. coli L‐asparaginase in man
Author(s) -
Oettgen Herbert F.,
Stephenson Phyllis A.,
Schwartz Morton K.,
Leeper Robert D.,
Tallal Lisa,
Tan Charlotte C.,
Clarkson Bayard D.,
Golbey Robert B.,
Krakoff Irwin H.,
Karnofsky David A.,
Murphy M. Lois,
Burchenal Joseph H.
Publication year - 1970
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197002)25:2<253::aid-cncr2820250204>3.0.co;2-u
Subject(s) - lethargy , medicine , toxicity , vomiting , azotemia , nausea , hypoproteinemia , gastroenterology , liver function , pancreatitis , renal function
During therapeutic trials with E. coli L‐asparaginase in 131 children and 143 adults with neoplastic disease the following signs of toxicity have been observed: fever, nausea and vomiting, weight loss, somnolence, lethargy, confusion, hypolipidemia, hyperlipidemia, hypoproteinemia, abnormal liver function tests, fatty metamorphosis of the liver, pancreatitis (in rare instances), azotemia, granulocytopenia, lymphopenia, thrombocytopenia, and hypersensitivity reactions. While these effects have been moderately severe and reversible in most instances, some patients have shown dangerous degrees of toxicity. This has been the case most frequently in adult patients receiving a dose of 5000 IU/kg/day.