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Vincristine sulfate and radiation therapy in metastatic Wilms' tumor
Author(s) -
Vietti Teresa J.,
Sullivan Margaret P.,
Haggard Mary E.,
Holcomb Thomas M.,
Berry Daisilee H.
Publication year - 1970
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197001)25:1<12::aid-cncr2820250104>3.0.co;2-n
Subject(s) - medicine , vincristine , wilms' tumor , radiation therapy , regimen , oncology , chemotherapy , cyclophosphamide
Complete regression of metastatic disease occurred in 16 of 22 (73%) children with Wilms' tumor treated with a combination regimen employing vincristine sulfate (Vcr) and radiation to the metastases. Ten of the 22 (45%) children are living and well for more than 2 years following treatment of their metastases. This survival figure might have been improved by more intensive radiation therapy, since 3 of the children failed to receive radiation therapy to all known metastatic sites. The response rate and quality and duration of response to Vcr plus radiation appear similar if not superior to that reported for actinomycin D plus radiation therapy in the treatment of metastatic Wilms'.