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Endolymphatic radiotherapy. A comparison of radiogold and radioiodine against the VX2 tumor in the rabbit
Author(s) -
LloydDavies R. W.,
Edwards J. M.,
Kinmonth J. B.
Publication year - 1969
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196911)24:5<938::aid-cncr2820240511>3.0.co;2-l
Subject(s) - medicine , lipiodol , lymph node , nuclear medicine , significant difference , incidence (geometry) , radiation therapy , radioiodine therapy , surgery , pathology , thyroid , thyroid carcinoma , embolization , physics , optics
Comparison of the radioisotopes of iodine and gold was made by a controlled trial treating lymph node metastases from VX2 tumor in the rabbit by the endolymphatic route. Control animals received tumor inoculation only, and 2 further groups received either 4mCi 131 I radioiodine in ultrafluid lipiodol or 8mCi Au 198 colloidal radiogold. The primary tumor was excised at 8 to 10 days after inoculation in all animals. Pelvic node weight was the main factor on which the trial was assessed. A significant difference in node weight was found between the treated and control groups, but there was no significant difference between the treated groups. No significant increased incidence of lung metastases was found in animals receiving endolymphatic infusions.