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Multiple osteogenic sarcomata — Metastatic or multicentric? Report of two cases and review of literature
Author(s) -
Amstutz Harlan C.
Publication year - 1969
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196911)24:5<923::aid-cncr2820240509>3.0.co;2-e
Subject(s) - medicine , sarcoma , natural history , osteosarcoma , lesion , metastatic tumor , pathology , metastasis , cancer
Osteogenic sarcomata in 2 adolescent girls are reported with multiple, almost simultaneously arising tumors suggesting the possibility of multiple de novo growths. However, in both patients reported here, as well as those from the literature, the first noted tumor was larger than a second symmetrically located lesion. The natural history of other multiple osteogenic sarcomas is reviewed illustrating a remarkable variability of clinical course including a relatively low grade but miliary osteogenic sarcoma in adults and the more typical metastatic osteogenic sarcoma. An age and sex difference is suggested. It is concluded that the multicentric origin cannot be established.