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A cellular and malignant blue nevus: A light and electron microscopic study
Author(s) -
Merkow Leonard P.,
Burt Robert C.,
Hayeslip David W.,
Newton Frank J.,
Slifkin Malcolm,
Pardo Matias
Publication year - 1969
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196911)24:5<888::aid-cncr2820240505>3.0.co;2-8
Subject(s) - pathology , melanoma , medicine , neoplasm , blue nevus , nevus , lymph , lesion , soft tissue , anatomy , cancer research
A rare malignant blue nevus resected from the back of a 34‐year‐old Caucasian woman is reported. Histopathologic examination showed the presence of a CBN as well as MBN. The CBN elements of this lesion showed the characteristic prominent neural type fascicles intertwined with melanocytes. The deeper regions of this skin neoplasm showed considerable variation in histopathologic patterns. Metastascs to the axillary lymph nodes and multiple subdermal soft tissue sites, invasion of the underlying skeletal muscle, and several recurrences in the chest wall indicate that this neoplasm is malignant, though of a lower order than a malignant melanoma. The ultrastructural characteristics of neoplastic cells indicate that this neoplasm is of Schwann cell origin.