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Enzyme histochemical study of primary hepatic carcinoma in thailand
Author(s) -
Stitnimankarn Tinrat,
Thakerngpol Kleophant
Publication year - 1969
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196911)24:5<1064::aid-cncr2820240530>3.0.co;2-i
Subject(s) - alkaline phosphatase , parenchyma , enzyme , pathology , oxidative enzyme , biopsy , glutamate dehydrogenase , carcinoma , liver parenchyma , lactate dehydrogenase , isocitrate dehydrogenase , succinate dehydrogenase , hepatocellular carcinoma , acid phosphatase , medicine , biology , biochemistry , glutamate receptor , receptor
A histochemical study of a number of hydrolytic and oxidative enzymes was made on 29 surgical biopsy and 15 postmortem specimens of primary hepatic carcinoma. Alkaline phosphatase could not be demonstrated in tumor tissue from any of the 44 cases studied. Lactate and isocitric dehydrogenases, and DPNH‐diaphorase showed greater intensities of reaction in a majority of the tumors as compared with nontumorous parenchyma on the same slides. Enzyme reactions appeared to be greater in the liver tissue than in the tumor nodules in a majority of cases for glucose‐6‐phosphate, glutamate, beta‐hydroxybutyric, and 6‐phosphogluconate dehydrogenases. This difference was most prominent in the last 2 enzymes. Dihydro‐orotate dehydrogenase and TPNH‐diaphorase gave variable results. Similar results were obtained in both surgical biopsy and postmortem specimens. No consistent differences in the reactions of the tumor tissues were observed in relation to the presence or absence of cirrhosis. Enzymatic activities of carcinomas of the liver were not related with the morphological grade of differentiation.