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Metastatic carcinoma simulating agnogenic myeloid metaplasia and myelofibrosis
Author(s) -
Kiely Joseph M.,
Silverstein Murray N.
Publication year - 1969
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196911)24:5<1041::aid-cncr2820240526>3.0.co;2-c
Subject(s) - medicine , myelofibrosis , metaplasia , carcinoma , pathology , bone marrow , myeloid , anemia , gastroenterology
Eight patients with metastatic carcinoma with findings simulating agnogenic myeloid metaplasia and myelofibrosis are reported. All patients had a previous histologic diagnosis of carcinoma and complained of bone pain. All had leukoerythroblastic anemia and reticulocytosis. Splenomegaly, observed in 6 of the 8 patients, was striking in only 2. Bone marrow examination in 6 patients revealed fibrosis in all 6, and carcinoma cells were demonstrable in 4. Osseous roentgenographic changes, observed in all 8 patients, were lytic, blastic, or mixed. Clinical differentiation from agnogenic myeloid metaplasia may be difficult but is possible. Long survival after the onset of myeloid metaplasia with metastatic carcinoma may occur; 3 of our patients were living more than 2 years after onset of the disorder.