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X‐ray therapy in a case of acute granulocytic leukemia. A cytogenetic study
Author(s) -
Anday George J.,
Tishkoff Garson
Publication year - 1969
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196910)24:4<826::aid-cncr2820240426>3.0.co;2-m
Subject(s) - medicine , bone marrow , pathology , lymph node , infiltration (hvac) , lymph , radiation therapy , leukemia , lymphoma , acute leukemia , immunology , physics , thermodynamics
A 44‐year‐old woman with cervical lymph node enlargement was thought at first to be suffering from malignant lymphoma. The cervical lymph nodes were x‐irradiated, with resulting decrease in size. Months later, the initially normal blood picture changed, a bone marrow aspirate showed dense myeloblastic infiltration, and the diagnosis of acute granulocytic leukemia was established. This was the time when our study was performed on bone marrow aspirate and peripheral blood. Cytogenetic analysis of the bone marrow aspirate revealed mostly diploid chromosome constitution with fuzzy outlines of the chromosomes, but without structural changes. The blood cultures, however, showed wide spectrum of structural alterations. The discrepancy is explained by the 2 different sources of study yielding 2 different cell types—myeloblasts in the bone marrow, but mostly radiation‐effected lymphocytes in the blood cultures.