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Atypical epithelial hyperplasia associated with breast cancer and fibrocystic disease
Author(s) -
Kern William H.,
Brooks Robert N.
Publication year - 1969
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196910)24:4<668::aid-cncr2820240403>3.0.co;2-t
Subject(s) - medicine , apocrine , papillomatosis , breast cancer , fibrocystic breast disease , pathology , atypia , metaplasia , atypical hyperplasia , carcinoma in situ , fat necrosis , hyperplasia , lobular carcinoma , carcinoma , breast disease , cancer , ductal carcinoma
Sections from grossly uninvolved areas of 100 radical mastectomies for breast cancer and sections from 100 partial mastectomies for fibrocystic disease were randomized and reviewed for various histologic features. Cystic disease was found in 71% of the breast cancer cases and was nearly as common as in the benign breasts. Inflammation, fat necrosis, sclerosing adenosis, apocrine metaplasia, and lobular hyperplasia were more common in benign cystic disease, but duct papillomatosis was slightly more commonly associated with breast cancer. Of 42 cases with atypical duct hyperplasia, 24 were found in the cancer group. All 7 cases that were considered of a borderline nature or included in‐situ carcinoma were associated with breast carcinoma, and none of the fibrocystic disease cases showed atypia of this degree.