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Chronic myelocytic leukemia. Chromosome studies of a patient and his nonleukemic identical twin
Author(s) -
Bauke J.
Publication year - 1969
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196909)24:3<643::aid-cncr2820240333>3.0.co;2-6
Subject(s) - myelocytic leukemia , medicine , concordance , chromosome , identical twins , leukemia , bone marrow , genetics , pathology , immunology , biology , physiology , gene
The chromosome constitution of peripheral blood cells and bone marrow cells was studied in a 31‐year‐old man with chronic myelocytic leukemia and his normal identical twin. Evidence for their identity includes similar physical appearance, identical blood group antigens and serum factors, similar fingerprint patterns, and phenylthiocarbamide tasting. A typical Philadelphia chromosome was found in the patient. It was absent in bone marrow metaphases of the nonleukemic twin, 8‐1/2 years after diagnosis of leukemia in the other twin. This supports the view that the Philadelphia chromosome is not inherited. To obtain more information about the concordance rate of monozygotic twins, all affected twin pairs should be reported, and long‐term follow‐up observations are needed.