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Nodular renal blastema. Definition and possible significance
Author(s) -
Bove K. E.,
Koffler H.,
McAdams A. J.
Publication year - 1969
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196908)24:2<323::aid-cncr2820240215>3.0.co;2-k
Subject(s) - blastema , pathology , trisomy , wilms' tumor , autopsy , medicine , kidney , anatomy , biology , regeneration (biology) , genetics , microbiology and biotechnology
A survey of autopsy records disclosed 8 infants in whom multiple small discrete nodules of primitive, undifferentiated derivatives of the renal blastema persisted in the subcapsular renal cortex. These were histologically similar to nephroblastoma (Wilms' tumor), although the character of the cells was usually undifferentiated rather than distinctly stromal or epithelial. Nodules of renal blastema were associated with multiple congenital anomalies in all cases and were detected in serial sections of 5 of 8 cases with the Trisomy 18 syndrome. Evidence was found that these nodules often retained a capacity for differentiation into dysplastic nephrons, and a possible relationship to cystic renal changes in Trisomy 18 is suggested. Dysplastic lesions, similar in location and appearance were found in 8 of 46 patients with Wilms' tumor. Because the incidence and type of congenital anomalies associated with Trisomy 18 and Wilms' tumor differ, and because Wilms' tumor is rare among children with Trisomy 18, nodular renal blastema is considered to be nonneoplastic. Its potential for neoplastic transformation is, however, unknown.