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A study of tobacco carcinogenesis. X. tumor promoting activity
Author(s) -
Wynder Ernest L.,
Hoffmann Dietrich
Publication year - 1969
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196908)24:2<289::aid-cncr2820240212>3.0.co;2-8
Subject(s) - bioassay , third hand smoke , smoke , medicine , cigarette smoke , tobacco smoke , carcinogenesis , toxicology , cancer , sidestream smoke , environmental health , biology , chemistry , genetics , organic chemistry
Cigarette smoke condensate has been shown to have tumor‐promoting activity in the mouse skin bioassay system. The present study investigated the tumor‐promoting activity of tobacco extract and a variety of cigarette smoke condensates. On a gram‐to‐gram basis, the tumor promoting activity of a DMSO tobacco extract is similar to that of cigarette smoke condensate. In the setting of the present study, smoke condensate from cigarettes made wholly from tobacco stems showed no significant tumor‐promoting activity. Observations from this study should contribute towards the identification of the major tumor‐promoting agents in cigarette smoke condensate and tobacco extracts.