Premium
Effects of X‐irradiation on parameters of tumor growth, histology, and ultrastructure
Author(s) -
Fisher Edwin R.,
Fisher Bernard
Publication year - 1969
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196907)24:1<39::aid-cncr2820240105>3.0.co;2-v
Subject(s) - medicine , pathology , lung , ultrastructure , histology , irradiation , primary tumor , lymph , carcinoma , radiation therapy , mammary carcinoma , metastasis , cancer , physics , nuclear physics
X‐irradiation of transplants of Walker and mammary carcinomas in legs of Sprague‐Dawley and syngeneic C3H mice respectively resulted in inhibition of growth of these “primary” tumors. Yet, the incidence and extent of pulmonary metastases from irradiated Walker carcinoma were comparable to controls. Metastases in lymph nodes were decreased only after irradiation with 5000 rads. No pulmonary metastases were encountered in controls with transplants of mammary carcinoma, whereas approximately one third of those subjected to 2000 rads exhibited such lesions. Cells of both tumors exhibited histopathologic and ultrastructural aberrations at various times following irradiation which were distinct from the direct effect of this modality on cell structure. Cells of pulmonary metastases resembled those of untreated tumors. This information, as well as other considerations, suggest that these apparently reversible cellular mutations might be concerned with the metastases from these tumors. X‐irradiation of lungs and liver prior to intrajugular and intraportal inoculation of Walker tumor cells resulted in enhancement of “metastases” in these organs. This tumor bed effect appeared to be organ specific and was not related to trapping of tumor cells at these sites. On the other hand, prior irradiation of the limb inhibited growth of subsequent implants and, in some instances, regression was noted. Pulmonary and nodal metastases in this situation appeared related to the size of the “primary” growth. Although no analogies between these findings and clinical experiences are intended, nevertheless they emphasize the need for studies which might allow for proper evaluation of the efficacy of pre‐ and postoperative irradiation in the therapy of human neoplasms.