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The stromal theca cell and postmenopausal endometrial adenocarcinoma
Author(s) -
Fienberg Robert
Publication year - 1969
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196907)24:1<32::aid-cncr2820240104>3.0.co;2-i
Subject(s) - stromal cell , endometrial hyperplasia , theca , hyperplasia , medicine , endocrinology , ovary , adenocarcinoma , pathology , cancer
The ovaries found in 11 cases of postmenopausal endometrial adenocarcinoma were studied with the help of oxidative enzyme reactions and lipid, hematoxylineosin, and van Gieson stains. Stromal theca cells were found in the ovaries of 10 of the 11 cases with and without stromal hyperplasia and in one case, the ovaries contained small scars in a very cellular stroma representing involuted stromal theca cell groups. In the hematoxylin‐eosin stain, the stromal theca cells were obscured even in ovarian stromal hyperplasia, and the search for these cells was greatly facilitated by the utilization of a lipid stain and oxidative enzyme reactions. In view of the potential steroid hormone production of the stromal theca cell as indicated by the lipid and enzyme content and the high incidence of the cell in cases of postmenopausal endometrial carcinoma, it is concluded that attention should be directed to these cells and not to the previously reported ovarian stromal hyperplasia in studies of postmenopausal endometrial carcinoma.