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Chromosomes in bronchoscopic biopsies. From patients with bronchial adenoma, bronchogenic carcinoma, and from heavy smokers
Author(s) -
Falor William H.,
Gordon Michael,
Kaczala O. Andrij
Publication year - 1969
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196907)24:1<198::aid-cncr2820240125>3.0.co;2-a
Subject(s) - medicine , pathology , bronchogenic carcinoma , aneuploidy , adenoma , malignant transformation , carcinoma , biopsy , hyperplasia , lung , chromosome , biology , biochemistry , gene
Evidence in the literature suggests that chromosomal aberration may precede histologic change as the initial sign of malignant transformation. To test this important concept as it relates to benign, premalignant, and malignant pulmonary lesions, bronchoscopic biospy specimens were studied. In 6 smokers, and 1 patient with a bronchial adenoma, and 7 patients with bronchogenic carcinoma, bronchoscopic biopsies were obtained and subjected to the squash technique to release spreads of chromosomes. In the chronic smokers, varied stages of hyperplasia were present in the instrumental biopsies, however, no mitoses were found. Chromosomal aneuploidy marked the bronchial adenoma and all of the karyotypable bronchogenic carcinomas.