Premium
Hypoglycemia associated with extrapancreatic tumors. An immunofluorescent study
Author(s) -
Saeed S. M.,
Fine G.,
Horn R. C.
Publication year - 1969
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196907)24:1<158::aid-cncr2820240120>3.0.co;2-t
Subject(s) - hypoglycemia , medicine , guinea pig , insulin , endocrinology , cytoplasm , fluorescein , antigen , tumor cells , pathology , fluorescence , biology , immunology , cancer research , biochemistry , physics , quantum mechanics
The indirect immunofluorescent technique, utilizing guinea pig antibovine insulin and fluorescein‐labelled rabbit antiguinea pig globulin applied to sections and imprints of two mesodermal tumors with associated hypoglycemia, demonstrated the presence of insulin or an antigenically similar substance in die cytoplasm of the tumor cells. A causal relationship between the fluorescent antigen(s) in the tumor and the hypoglycemia was indicated in one instance by the alleviation of the hypoglycemia following the removal of the tumor. The second tumor was inoperable and both hypoglycemia and tumor persisted.