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The fine structure of methylcholanthrene‐induced tumors in mice
Author(s) -
Clarke Michael A.
Publication year - 1969
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196907)24:1<147::aid-cncr2820240119>3.0.co;2-7
Subject(s) - myofilament , pathology , in vitro , methylcholanthrene , in vivo , electron microscope , tumor cells , medicine , anatomy , chemistry , biology , microbiology and biotechnology , cancer research , myocyte , carcinogen , optics , biochemistry , physics
Light and electron microscopic examination of tumors induced in mice by the subcutaneous implantation of methylcholanthrene indicated the presence of fibrosarcomas and rhabdomyosarcomas. Tumors of the primary host, tumors of the first transplant generation, and tumor cells grown in vitro had similar fine structure. Rhabdomyoblasts, containing bundles of striated myofilaments, were seen in varying degrees of differentiation. Myofilaments were identified in one transplanted tumor but not in the cells grown in culture. Some cells contained identifiable myofilaments that were not seen with the light microscope. Virus‐like particles were observed frequently in vitro and uncommonly in vivo.