Premium
Spermatocytic seminoma. II. Ultrastructural study
Author(s) -
Rosai Juan,
Khodadoust Kavous,
Silber Igal
Publication year - 1969
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196907)24:1<103::aid-cncr2820240114>3.0.co;2-1
Subject(s) - ultrastructure , adherens junction , golgi apparatus , meiosis , microbiology and biotechnology , seminoma , cell junction , basement membrane , biology , anatomy , pathology , cell , medicine , cadherin , genetics , endoplasmic reticulum , chemotherapy , gene
Two cases of spermatocytic seminoma were examined by electron microscopy. The more important ultrastructural features were: prominent nucleolus with dispersed nucleolonema; occasional nuclei with die chromosomal configuration of the leptotene stage of meiotic prophase; marked development of die Golgi apparatus, with formation of a dense secretory product; basal bodies and ciliary rootlets; “lamellar bodies”; specialized cell junctions of the zonula adherens type; true intercellular bridges, identical to those normally found between spermatocytes and between spermatids; syncytial formations; and basal laminae (basement membranes). Comparison of these findings with those of classical seminomas suggests an origin from the same cell type but also indicates that spermatocytic seminoma is a tumor distinct from the former by virtue of its greater differentiation, as evidenced by its capacity to produce spermatocytes and possibly spermatids.