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Carcinoma of the breast, chronic lymphocytic leukemia, macroglobulinemia, eosinophilic chloroma and myelosclerosis—a unique association
Author(s) -
Benvenisti Dan S.,
Debellis Robert H.
Publication year - 1969
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196905)23:5<1204::aid-cncr2820230529>3.0.co;2-m
Subject(s) - medicine , breast carcinoma , chronic lymphocytic leukemia , macroglobulinemia , eosinophilic , pathology , leukemia , eosinophilia , carcinoma , immunology , lymphoproliferative disorders , lymphoma , breast cancer , cancer , multiple myeloma
A patient with carcinoma of the breast, chronic lymphocytic leukemia, macroglobulinemia, diffuse plasmacytosis, eosinophilic chloroma, and myelosclerosis is described. It is speculated that the lymphoproliferative disorders in this patient were the result of an immunologic reaction to the breast carcinoma. This immune response could have further initiated a marked eosinophilia which subsequently might have led to self‐perpetuating proliferation of the eosinophilic granulocytes as manifested by the development of eosinophilic chloroma. Alternatively, a unitarian concept is proposed by which a dysfunctioning multi‐potential stem cell may give rise to multiple diseases fitting into the categories of both the lymphoproliferative and myeloproliferative disorders.