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Bronchial artery perfusion for treatment of advanced lung cancer
Author(s) -
Cliffton Eugene E.
Publication year - 1969
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196905)23:5<1151::aid-cncr2820230521>3.0.co;2-g
Subject(s) - medicine , perfusion , lung cancer , chest pain , aorta , bronchial artery , surgery , pulmonary artery , artery , lumen (anatomy) , lung , balloon catheter , catheter , radiology
Twenty‐one patients with advanced lung cancer, limited to the chest, were treated by bronchial artery perfusion using 0.4 to 0.6 mg/kg of HN2 using a double lumen, double balloon aortic catheter. The infusion was made into the aorta between levels T4 and T8. Two patients were infused 2 times. There were no serious complications in these 21 patients. Average survival of the 21 treated patients was 8 months with a range from one day to 45 months. Symptoms were improved in the majority of treated patients. Cough was improved in 80%. Pain was completely relieved in 3, almost completely relieved in 2, and improved in 4–a total 9 of the 15 patients with severe, persistent pain. There was objective evidence of improvement in 12 patients. Five had objective measured improvement in pulmonary function and, in 7 of the 21 patients (32%), there was decrease in the size of the tumor mass as recorded on official x‐ray reports. Average survival in 6 patients considered for perfusion but not completed, because of technical difficulties, was 1.8 months with a range from 1 to 3 months.