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Histologic changes in incipient carcinoma of the breast
Author(s) -
Sommers Sheldon C.
Publication year - 1969
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196904)23:4<822::aid-cncr2820230416>3.0.co;2-3
Subject(s) - pathology , medicine , carcinoma , mammary carcinoma , mammary gland , stage (stratigraphy) , carcinoma in situ , breast cancer , cancer , biology , paleontology
The histopathologic grades, degrees of nuclear differentiation and lympho‐cytic infiltrates in 38 intraductal mammary carcinomas are compared with these features of 254 ordinary invasive carcinomas and 35 cases with special types of carcinoma, all clinically localized, Stage A. Significantly, more well‐differentiated carcinomas with differentiated nuclei occurred in the intraductal group, and more undifferentiated carcinomas with poorly differentiated nuclei were found among the invasive tumors. These discrepancies are believed to reflect enhanced invasion by less differentiated mammary carcinoma cells.